Preserve fertility and testicular function while on testosterone replacement therapy. The essential companion to TRT — prescribed by licensed Arizona providers.
Gonadorelin is a synthetic form of gonadotropin-releasing hormone (GnRH) — the hormone your hypothalamus uses to signal your pituitary to produce LH and FSH.
LH (luteinizing hormone) and FSH (follicle-stimulating hormone) are essential for testosterone production and fertility. When you're on exogenous testosterone (TRT), your body's natural GnRH signal shuts down — this means LH and FSH drop to near zero.
The result: testicular atrophy (shrinkage) and suppressed fertility (reduced or absent sperm production).
Gonadorelin maintains the GnRH signal, keeping your pituitary active and preserving testicular function and fertility while on TRT. It's the replacement for HCG in many TRT protocols following the FDA's reclassification of HCG as a biologic in 2020, which limited compounding pharmacy access.
Without it, TRT shuts down your HPT axis (hypothalamic-pituitary-testicular axis). Testicular atrophy is both a cosmetic concern and a fertility concern.
Men who want to preserve the option of having children while on TRT need GnRH or HCG. Gonadorelin is FDA-approved and available from compounding pharmacies — no supply issues like HCG.
Prescribed alongside TRT protocols to protect what testosterone alone can suppress.
Maintains LH and FSH production, keeping sperm production active while on testosterone.
Prevents testicular atrophy (shrinkage) that occurs with exogenous testosterone use.
Supports a more complete hormonal profile by keeping the HPT axis partially active.
Gonadorelin has a well-established safety profile with FDA approval as a diagnostic and therapeutic GnRH analog.
Both serve the same purpose: preserving fertility and testicular function on TRT.
The traditional TRT companion — mimics LH directly at the testes. Effective, but supply has been disrupted after the 2020 FDA reclassification as a biologic. Limited compounding pharmacy access.
Works upstream — stimulates your pituitary to produce its own LH and FSH. FDA-approved, widely available from compounding pharmacies. Considered the standard replacement for HCG in modern TRT protocols.
Your provider will recommend based on availability and your specific protocol.
Book a free consultation and your provider will determine if gonadorelin should be part of your protocol.
Book Free ConsultationIf you want to preserve fertility or prevent testicular atrophy, yes. Without GnRH or HCG, TRT suppresses your body's natural LH/FSH production, leading to shrinkage and potential infertility.
HCG mimics LH directly at the testes. Gonadorelin works upstream, stimulating your pituitary to produce its own LH and FSH. Both preserve testicular function; gonadorelin is more widely available since the 2020 HCG reclassification.
Gonadorelin helps maintain sperm production by keeping FSH active. However, fertility preservation while on TRT is not guaranteed. If fertility is a primary concern, discuss this thoroughly with your provider before starting TRT.
Gonadorelin is generally well-tolerated. Possible side effects include injection site reactions, headache, and occasionally nausea. Your provider monitors your hormonal markers regularly.
Primarily, yes. Gonadorelin is most commonly prescribed as a TRT companion. It can also be used diagnostically to assess pituitary function. Your provider will determine if it's appropriate for your situation.
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