The mitochondrial-derived peptide that regulates metabolic homeostasis. Exercise capacity, insulin sensitivity, and longevity optimization.
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a peptide encoded within mitochondrial DNA. It's one of the first identified "mitochondrial-derived peptides" (MDPs) -- signaling molecules produced by mitochondria that regulate whole-body metabolism.
MOTS-c activates AMPK (AMP-activated protein kinase), the master metabolic regulator -- the same pathway activated by exercise and metformin. It essentially mimics some of the metabolic benefits of exercise at the cellular level.
MOTS-c levels decline with age, correlating with metabolic decline. This peptide targets the biohacker and longevity crowd -- people who understand mitochondrial health and want to optimize metabolic function at its source.
MOTS-c targets the fundamental metabolic pathways that decline with age.
Activates AMPK, the master metabolic switch. Improves glucose metabolism and insulin sensitivity at the cellular level.
Acts as an "exercise mimetic" -- supports the metabolic adaptations that come from physical training. Amplifies your workouts.
Promotes fatty acid oxidation and healthy body composition through metabolic regulation, not appetite suppression.
One of the most exciting molecules in longevity science. MOTS-c levels correlate with metabolic health and healthy aging.
MOTS-c targets the folate-methionine cycle, which affects cellular methylation -- a fundamental process in gene regulation. This is one of the mechanisms through which it influences whole-body metabolic homeostasis.
In animal studies, MOTS-c has reversed age-related metabolic decline and improved physical performance even in aged subjects. The results have generated significant excitement in the longevity research community.
Human studies are earlier-stage but promising, showing improvements in insulin sensitivity and metabolic markers. As more clinical data emerges, MOTS-c is positioning itself as one of the most compelling molecules in metabolic and longevity science.
Book a free consultation to discuss your goals. Your provider will design a personalized MOTS-c protocol tailored to you.
Book Free ConsultationYes. MOTS-c is available now at Voxy, prescribed by licensed telehealth providers in Arizona. Book a free consultation to get started.
No. MOTS-c mimics some metabolic effects of exercise but is not a replacement for physical activity. It's best understood as a metabolic optimizer that amplifies training adaptations.
Patients interested in metabolic optimization, longevity, and performance. It's particularly relevant for patients with insulin resistance, metabolic syndrome, or those in the biohacking/longevity space.
MOTS-c is a naturally occurring peptide in the body. Research to date shows a favorable safety profile. Mild injection site reactions are possible. As with all peptides, your provider monitors your response.
Yes. MOTS-c pairs well with NAD+ (both target cellular energy pathways) and with GH peptides for comprehensive metabolic and body composition optimization.
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